Original Histidine-Tryptophan-Ketoglutarate solution (HTK) developed by Professor Hans J. Bretschneider and Dr. Franz J. Köhler
Worldwide accepted as a standard in organ protection
Preferred protection solution in over 90 countries worldwide
Over 3 Million performed surgeries
Clinically proven: over 900 peer-reviewed articles prove safety and reliability
CUSTODIOL
Simple like water, easier and more convenient for operation
Truly ready-to-use: no filters or additives are necessary, simple perfusion technique
More convenient for operation: save staff time effectively, avoid risk of contamination
Only one single initial application by using a simple perfusion technique
A single/initial application applied over the period of 6-8 minutes is sufficient for up to 180 minutes of myocardial ischemia
Water-like viscosity: quick flushing, sufficient perfusion, and rapid homogenous cooling of organs
Low concentration of potassium: no need for a pre-flush
Crystalloid solution: allows a quite blood-free view for the surgeon, especially beneficial for minimal-invasive surgeries and complicated cardiac surgeries
CUSTODIOL
Powerful like water, one solution for most organs
In situ protection
Heart surgery
Kidney tumour resection
Preservation of blood vessels
Organ transplantation
Multi-organ procurement
Protection of all kinds of organs (including those from ECD and DCD)
Split liver donation
CUSTODIOL
Good like water, more safety
Intracellular solution: the electrolyte composition is close to cytoplasmic levels
High systemic tolerance: all constituents are naturally occurring physiological substances (except for the inert mannitol)
High ischemic tolerance: even at increasing temperatures at end of surgery
Low concentration of sodium and calcium: no intracellular overload or irregular activities
Histidine buffer: high organic buffer capacity prevents metabolic acidosis
Tryptophan: protection of cell membranes
Ketoglutarate: energy substrate for production of ATP
Mannitol: osmotic diuretic protecting against oedema formation
Radical scavengers: histidine and mannitol act as anti-oxidants
Physiological osmolarity: no formation of oedema, no neurological implications