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CUSTODIOL 
Clear like water, German Original

  • Original Histidine-Tryptophan-Ketoglutarate solution (HTK) developed by Professor Hans J. Bretschneider and Dr. Franz J. Köhler
  • Worldwide accepted as a standard in organ protection
  • Preferred protection solution in over 90 countries worldwide
  • Over 3 Million performed surgeries
  • Clinically proven: over 900 peer-reviewed articles prove safety and reliability

CUSTODIOL 
Simple like water, easier and more convenient for operation

  • Truly ready-to-use: no filters or additives are necessary, simple perfusion technique
  • More convenient for operation: save staff time effectively, avoid risk of contamination
  • Only one single initial application by using a simple perfusion technique
  • A single/initial application applied over the period of 6-8 minutes is sufficient for up to 180 minutes of myocardial ischemia
  • Water-like viscosity: quick flushing, sufficient perfusion, and rapid homogenous cooling of organs
  • Low concentration of potassium: no need for a pre-flush
  • Crystalloid solution: allows a quite blood-free view for the surgeon, especially beneficial for minimal-invasive surgeries and complicated cardiac surgeries

CUSTODIOL 
Powerful like water, one solution for most organs

In situ protection

  • Heart surgery
  • Kidney tumour resection
  • Preservation of blood vessels

Organ transplantation

  • Multi-organ procurement
  • Protection of all kinds of organs (including those from ECD and DCD)
  • Split liver donation

CUSTODIOL 
Good like water, more safety

  • Intracellular solution: the electrolyte composition is close to cytoplasmic levels
  • High systemic tolerance: all constituents are naturally occurring physiological substances (except for the inert mannitol)
  • High ischemic tolerance: even at increasing temperatures at end of surgery
  • Low concentration of sodium and calcium: no intracellular overload or irregular activities
  • Histidine buffer: high organic buffer capacity prevents metabolic acidosis
  • Tryptophan: protection of cell membranes
  • Ketoglutarate: energy substrate for production of ATP
  • Mannitol: osmotic diuretic protecting against oedema formation
  • Radical scavengers: histidine and mannitol act as anti-oxidants
  • Physiological osmolarity: no formation of oedema, no neurological implications