CUSTODIOL
Pancreas transplantation

• Low volumes needed: The physico-chemical characteristics of CUSTODIOL allow for a fast cooling and perfusion with only a few litres until the effluent is clear
• No additional flushing of the pancreas: Unlike other organs, flushing of the pancreas ex vivo (before implantation) is probably not necessary and may be even harmful to the microcirculation. CUSTODIOL does not require an extra step of flushing due to its low potassium content
• Suitable for islet transplantation: Recent reports confirm advantages of using CUSTODIOL for in-situ flush of pancreata prior to subsequent islet isolation
• Excellent postoperative recovery: Good endocrine and exocrine function of pancreatic tissue

Clinical Outcomes of CUSTODIOL, Viaspan (UW), Celsior (CS): Survival & Pancreatitis⁵⁾

Pancreatitis was diagnosed more commonly with Celsior solution. There were no differences in postoperative events such as thrombosis, pancreatitis, pancreatic or intestinal fistula, need for re-operation or retransplantation, and acute cellular or humoral rejection.

5) Montiel-Casado MC, Pérez-Daga JA, Blanco-Elena JA, Aranda-Narváez JM, Sánchez-Pérez B, Cabello-Díaz M, Ruiz-Esteban P, León-Díaz FJ, Gutiérrez-de la Fuente C, Santoyo-Santoyo J. Pancreas Preservation With Viaspan, Celsior, and Custodiol Solutions: An Initial Experience. Transplant Proc. 2016 Nov;48(9):3040-3042

CUSTODIOL should be preferred over UW for the preservation of pancreata⁶⁾

Data generated at the University Clinic of Bochum demonstrate excellent long-term survival of 85% at 10 years. The equivalence of the preservation with CUSTODIOL and UW solution in terms of prevention of organ damage in pancreas (-kidney) transplantation was demonstrated in a retrospective study. CUSTODIOL showed a significant advantage with respect to graft survival, at a maximum cold ischemia time of 12 hours.

 6) Richard Viebahn, MD, Department of Surgery, University Hospital of Bochum, Bochum, Germany. Improving outcomes with optimised organ preservation prior to transplantation. Symposium at the Congress of the European Society for Organ Transplantation (ESOT) in Brussels, 15th September 2015