CUSTODIOL 
Vascularized composite allotransplantation

• Lesser degree of inflammation and tissue damage
• CUSTODIOL is the standard preservation solution for the rare and complex procedures of composite tissue procurement

CUSTODIOL Protects composite tissue against inflammation⁷⁾

Histopathologic scores of tissue sections of saline-, CUSTODIOL, and UW-treated animals (2-30 hours of cold ischemia) revealed the following results:

• Skin tissue
  

  A decrease of inflammation in CUSTODIOL-treated limbs was observed in the skin. The UW preservation solution did not positively influence skin inflammation compared to saline-treated limb

  
  

• Muscle tissue

  In the muscle, inflammation and tissue damage were reduced in the 10h group using CUSTODIOL when compared to saline. UW solution did not show a positive impact on muscle preservation compared to saline-treated limbs

  
  

• Nerve tissue

  Both CUSTODIOL and UW slightly limited nerve damage and inflammation in the 10h group but not in the 2h and 30h groups

7) Hautz T, Hickethier T, Blumer MJ, Bitsche M, Grahammer J, Hermann M, Zelger B, Messner F, Pechriggl EJ, Krapf C, Kimelman M, Brandacher G, Lee WP, Margreiter R, Pratschke J, 

Schneeberger S. Histomorphometric evaluation of ischemia-reperfusion injury and the effect of preservation solutions histidine-tryptophan-ketoglutarate and University of Wisconsin in limb transplantation. Transplantation. 2014 Oct 15;98(7):713-20